Analysis of inflammatory cytokines and estimated glomerular filtration rate decline in Japanese patients with diabetic kidney disease: a pilot study-Reference-Cited by-同舟云学术

Analysis of inflammatory cytokines and estimated glomerular filtration rate decline in Japanese patients with diabetic kidney disease: a pilot study

Published:2022-07 Issue:10 Volume:16 Page:759-770
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Sugawara Yuka¹^ORCID,Hirakawa Yosuke¹^ORCID,Mise Koki²^ORCID,Kashiwabara Kosuke³^ORCID,Hanai Ko⁴^ORCID,Yamaguchi Satoshi²^ORCID,Katayama Akihiro²^ORCID,Onishi Yasuhiro²^ORCID,Yoshida Yui¹^ORCID,Kashihara Naoki⁵^ORCID,Matsuyama Yutaka⁶^ORCID,Babazono Tetsuya⁴,Nangaku Masaomi¹^ORCID,Wada Jun²^ORCID

Affiliation:

1. Division of Nephrology & Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, 113 8655, Japan

2. Department of Nephrology, Rheumatology, Endocrinology & Metabolism, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Okayama, 700 8558, Japan

3. Data Science Office, Clinical Research Promotion Center, The University of Tokyo Hospital, Tokyo, 113 8655, Japan

4. Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, 162 8666, Japan

5. Department of Nephrology & Hypertension, Kawasaki Medical School, Kurashiki, 701 0192, Japan

6. Department of Biostatistics, The University of Tokyo, Tokyo, 113 0033, Japan

Abstract

Background: It is important to identify additional prognostic factors for diabetic kidney disease. Materials & methods: Baseline levels of ten cytokines (APRIL/TNFSF13, BAFF/TNFSF13B, chitinase 3-like 1, LIGHT/TNFSF14, TWEAK/TNFSF12, gp130/sIL-6Rβ, sCD163, sIL-6Rα, sTNF-R1, sTNF-R2) were measured in two cohorts of diabetic patients. In one cohort (n = 777), 156 individuals were randomly sampled after stratification and their plasma samples were analyzed; in the other cohort (n = 69), serum samples were analyzed in all the individuals. The levels of cytokines between rapid (estimated glomerular filtration rate decline >5 ml/min/1.73 m2/year) and non-rapid decliners were compared. Results: Multivariate analysis demonstrated significantly high levels of LIGHT/TNFSF14, TWEAK/TNFSF12 and sTNF-R2 in rapid decliners. Conclusion: These three cytokines can be potential biomarkers for the progression of diabetic kidney disease.

Funder

Japan Agency for Medical Research and Development

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2021-1104

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