Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients

Author:

Nádasdi Ákos1ORCID,Sinkovits György2ORCID,Bobek Ilona3ORCID,Lakatos Botond4ORCID,Förhécz Zsolt5ORCID,Prohászka Zita Z2,Réti Marienn6,Arató Miklós1ORCID,Cseh Gellért1,Masszi Tamás5ORCID,Merkely Béla7ORCID,Ferdinandy Péter87ORCID,Vályi-Nagy István9,Prohászka Zoltán2ORCID,Firneisz Gábor1ORCID

Affiliation:

1. Ramgen Plc., Budapest, H-1126, Hungary

2. Department of Internal Medicine & Haematology, Research Laboratory, Semmelweis University, Budapest, H-1088, Hungary

3. Department of Anaesthesiology & Intensive Care Medicine, Central Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary

4. Department of Infectology, Central Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary

5. Department of Internal Medicine & Haematology, Semmelweis University, Budapest, H-1088, Hungary

6. Department of Haematology & Stem Cell Transplantation, Central Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary

7. Semmelweis University, Budapest, H-1085, Hungary

8. Department of Pharmacology & Pharmacotherapy, Semmelweis University, Budapest, H-1089, Hungary

9. Central Hospital of Southern Pest, National Institute of Haematology & Infectious Diseases, Budapest, H-1097, Hungary

Abstract

Aim: To investigate the serum circulating DPP4 activity in patients with COVID-19 disease. Materials & methods: Serum samples from 102 hospitalized COVID-19 patients and 43 post-COVID-19 plasma donors and 39 SARS-CoV-2 naive controls and their medical data were used. Circulating DPP4 activities according to different COVID-19 disease peak severity (WHO) groups at sampling and at peak were assessed. Results: A significant decrease (p < 0.0001) in serum DPP4 activity was found in study groups of higher disease severity. When the circulating DPP4 activity was assessed as a prognostic marker, the logistic regression (p = 0.0023) indicated that the enzyme activity is a predictor of mortality (median 9.5 days before death) with receiver operating characteristic area under the curves of 73.33% (p[area = 0.5] < 0.0001) as single predictor and 83.45% (p[area = 0.5] < 0.0001) in combination with age among hospitalized patients with COVID-19. Conclusion: Decreased circulating DPP4 activity is associated with severe COVID-19 disease and is a strong prognostic biomarker of mortality.

Funder

Ramgen Plc.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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