Direct effects of transforming growth factor-β1 signaling on the differentiation fate of fetal hepatic progenitor cells-Reference-Cited by-同舟云学术

Direct effects of transforming growth factor-β1 signaling on the differentiation fate of fetal hepatic progenitor cells

Published:2020-06 Issue:6 Volume:15 Page:1719-1733
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Yasen Aimaiti¹²^ORCID,Li Wending¹,Maimaitinijiati Yusufukadier¹,Aini Abudusalamu¹,Ran Bo²,Wang Hui³,Tuxun Tuerhongjiang⁴,Shao Yingmei²,Aji Tuerganaili²,Wen Hao²⁵

Affiliation:

1. Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, Urumqi 830011, PR China

2. Department of Hepatobiliary & Hydatid Disease, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, Urumqi 830054, PR China

3. Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, Urumqi 830054, PR China

4. Department of Liver & Laparoscopic Surgery, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, Urumqi 830054, PR China

5. State Key Laboratory of Pathogenesis, Prevention & Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, 393 Xin Yi Road, Urumqi 830011, PR China

Abstract

Aim: To investigate direct roles of TGF-β1 signaling in the differentiation process of fetal hepatic progenitor cells (HPCs). Materials & methods: Exogenous TGF-β1 and SB431542 were added into fetal HPCs. Then, SB431542 was intraperitoneally injected into pregnant mice for 8 days. Results: Fetal HPCs treated with TGF-β1 differentiated into cholangiocytes. However, hepatocyte marker was highly expressed after inhibiting TGF-β1 signaling. In vivo, hematopoietic cells were gradually replaced with liver cells and TGF-β1 expression was evidently decreased as fetal liver developed. Inhibition of TGF-β1 signaling caused increase of ALB+ cells, but CK19 expression was more obvious in control mice livers. Conclusion: TGF-β1 signaling may play decisive roles in fetal HPCs differentiation into functional hepatocytes or cholangiocytes.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2020-0002

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