A new model of chronic peripheral nerve compression for basic research and pharmaceutical drug testing-Reference-Cited by-同舟云学术

A new model of chronic peripheral nerve compression for basic research and pharmaceutical drug testing

Published:2021-10 Issue:10 Volume:16 Page:931-947
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Degrugillier Lucas¹²³,Prautsch Katharina M¹²³,Schaefer Dirk J³,Guzman Raphael⁴,Schären Stefan⁵,Kalbermatten Daniel F³⁶⁷,Madduri Srinivas²³⁶⁷^ORCID

Affiliation:

1. Department of Pathology, University Hospital Basel, Basel, 4021, Switzerland

2. Department of Biomedical Engineering, University of Basel, Allschwil, 4123, Switzerland

3. Department of Plastic, Reconstructive, Aesthetic & Hand Surgery, University Hospital Basel, University of Basel, Basel, 4021, Switzerland

4. Department of Neurosurgery, University Hospital Basel, University of Basel, Basel, 4021, Switzerland

5. Department of Spinal Surgery, University Hospital Basel, Basel, 4021, Switzerland

6. Bioengineering & Neuroregeneration, Department of Surgery, Geneva University Hospitals & University of Geneva, 1211, Geneva, Switzerland

7. Plastic, Reconstructive & Aesthetic Srugery, Department of Surgery, Geneva University Hospitals & University of Geneva, 1211, Geneva, Switzerland

Abstract

Aim: To develop a consistent model to standardize research in the field of chronic peripheral nerve neuropathy. Methods: The left sciatic nerve of 8-week-old Sprague–Dawley rats was compressed using a customized instrument leaving a defined post injury nerve lumen (400 μm, 250 μm, 100 μm, 0 μm) for 6 weeks. Sensory and motor outcomes were measured weekly, and histomorphology and electrophysiology after 6 weeks. Results: The findings demonstrated compression depth-dependent sensory and motor pathologies. Quantitative measurements revealed a significant myelin degeneration, axon irregularities and muscle atrophy. At the functional level, we highlighted the dynamics of the different injury profiles. Conclusion: Our novel model of chronic peripheral nerve compression is a useful tool for research on pathophysiology and new therapeutic approaches.

Funder

Eurostars

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2020-0129

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