Acute kidney injury in the elderly: pathogenesis, diagnosis and therapy

Abstract

Elderly patients, especially those with chronic kidney disease, are at least a 3.5-fold higher risk for the development of acute kidney injury (AKI). With aging, renal functional reserve is lower owing to specific cellular changes that affect function. Molecular studies are elucidating these cellular changes and offer the prospect of designing novel therapeutics. The spectrum of AKI in elderly patients is wide but is over-represented by prerenal and postrenal (obstructive) etiologies. This reflects potentially nephrotoxic clinical variables, such as combordid states, impaired baseline renal function, polypharmacy and an increase in high-risk procedures. In this population, the development of AKI can lead to longer hospital stays, higher mortality rates and an increased risk for the development of chronic kidney disease and end-stage renal disease. Careful attention to clinical risk factors, avoidance of nephrotoxic insults and meticulous supportive care for patients who develop AKI is critical in alleviating the burden of this problem.