Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder-Reference-Cited by-同舟云学术

Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder

Published:2018-12 Issue:12 Volume:10 Page:1585-1601
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Uddin Monica¹²,Ratanatharathorn Andrew³,Armstrong Don¹,Kuan Pei-Fen⁴,Aiello Allison E⁵,Bromet Evelyn J⁶,Galea Sandro⁷,Koenen Karestan C⁸⁹¹⁰,Luft Benjamin¹¹,Ressler Kerry J¹²,Wildman Derek E¹¹³,Nievergelt Caroline M¹⁴¹⁵,Smith Alicia¹⁶

Affiliation:

1. Carl R Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA

2. Department of Psychology, University of Illinois Urbana-Champaign, 603 East Daniel St, Champaign, IL 61820, USA

3. Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th St, NY 10032, USA

4. Department of Applied Mathematics & Statistics, Stony Brook University, John S Toll Drive, Stony Brook, NY 11794, USA

5. Department of Epidemiology, Gillings School of Public Health, University of North Carolina, 135 Dauer Drive, Chapel Hill, NC 27599, USA

6. Department of Psychiatry, Stony Brook University School of Medicine, 101 Nicolls Rd, Stony Brook, NY 11794, USA

7. Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA

8. Department of Epidemiology, Harvard TH Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA

9. Psychiatic & Neurodevelopmental Genetics Unit & Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA

10. Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA 02142, USA

11. Department of Medicine, Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, NY 11794, USA

12. Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA

13. Department of Molecular & Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, Urbana, IL 61801, USA

14. Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093, USA

15. VA Center of Excellence for Stress & Mental Health, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA

16. Department of Psychiatry & Behavioral Sciences & Department of Obstetrics & Gynecology, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA

Abstract

Aim: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. Materials & methods: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium. Results: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). Conclusion: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2018-0049

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