The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation-Reference-Cited by-同舟云学术

The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation

Published:2018-11 Issue:11 Volume:10 Page:1445-1461
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Bush Nicole R¹²,Edgar Rachel D³,Park Mina⁴,MacIsaac Julia L³,McEwen Lisa M³,Adler Nancy E¹,Essex Marilyn J⁵,Kobor Michael S³,Boyce W Thomas¹²

Affiliation:

1. Department of Psychiatry, Center for Health & Community, Weill Neuroscience Institute, University of California, San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA

2. Department of Pediatrics, Division of Developmental Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA 94158, USA

3. Department of Medical Genetics, BC Children's Hospital, Centre for Molecular Medicine & Therapeutics, University of British Columbia, 950 West 28th Ave., Vancouver, BC V5Z 4H4, Canada

4. School of Population & Public Health, BC Children's Hospital, University of British Columbia, 4480 Oak St, Vancouver, BC V6H 3N1, Canada

5. Department of Psychiatry, University of Wisconsin, Madison,16330 Ellendale Road, Dallas, OR 97338, USA

Abstract

Aim: To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course. Materials & methods: In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined. Results: Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions. Conclusion: Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2018-0042

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