DNA amplifications in breast cancer: genotypic–phenotypic correlations

Author:

Shiu Kai-Keen1,Natrajan Rachael1,Geyer Felipe C1,Ashworth Alan,Reis-Filho Jorge S1

Affiliation:

1. The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, UK, SW3 6JB

Abstract

DNA copy number changes in cancer cells, in particular, amplifications, occur frequently, have prognostic impact and are associated with subtypes of breast cancer. Some amplicons contain well-characterized oncogenes, including 11q13 (CCND1) and 17q12 (HER2). HER2 amplification and overexpression defines the HER2+ subgroup of breast cancer patients and is both a prognostic marker for poor outcome and a predictive marker for response to anti-HER2 targeted therapies. Therefore, there is considerable interest in documenting the locations of other recurring amplifications in breast cancers as they may also provide a rich source of new biomarkers and novel therapeutic targets for these subgroups. This article focuses on the genomic profiling of breast cancer, with an emphasis on the characteristics of the amplifications found in subtypes of breast cancer, including luminal (ER+/HER2-), HER2+ and basal-like (ER-/HER2-), and discusses their known or potential roles in cancer biology and their clinical implications.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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