ABCB1 and SLCO1B1 gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia-Reference-Cited by-同舟云学术

ABCB1 and SLCO1B1 gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia

Published:2021-03 Issue:2 Volume:18 Page:107-114
ISSN:1741-0541
Container-title:Personalized Medicine
language:en
Short-container-title:Personalized Medicine

Author:

Srisuttayasathien Manasawee¹^ORCID,Areepium Nutthada²,Lertkhachonsuk Ruangsak¹^ORCID

Affiliation:

1. Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine, Chulalongkorn University & King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand

2. Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand

Abstract

Aim: The aim of this study was to explore the effects of ABCB1 and SLCO1B1 gene polymorphisms and the methotrexate (MTX) treatment response in patients with low-risk gestational trophoblastic neoplasia (GTN). Materials & methods: Low-risk GTN patients who received MTX as a first-line single agent were enrolled. DNA was extracted from peripheral blood samples from 18 patients and assessed for ABCB1 C3435T and SLCO1B1 T521C. Results: ABCB1 C3435T and SLCO1B1 T521C polymorphisms were not associated with the MTX response or toxicity in Thai patients Conclusion: The selected ABCB1 and SLCO1B1 polymorphism do not predict the risk of MTX resistance in low-risk GTN.

Funder

Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pme-2020-0089

Reference39 articles.

1. Royal College of Obstetricians and Gynaecologists. The Management of Gestational Trophoblastic Disease – Green-top Guideline No. 38 (2010).

2. The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: Description and critical assessment

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