Current advances in the diagnosis and personalized treatment of breast cancer: lessons from tumor biology

Author:

Kern Rodrigo12ORCID,Correa Stephany Christiane3ORCID,Scandolara Thalita Basso14ORCID,Carla da Silva Janaína12ORCID,Pires Bruno Ricardo56ORCID,Panis Carolina12ORCID

Affiliation:

1. Laboratory of Tumor Biology, State University of West Paraná, Francisco Beltrão – Paraná 85601-970, Brazil

2. Post-Graduation Program in Health-Applied Sciences, State University of West Paraná, Francisco Beltrão – Paraná 85601-970, Brazil

3. Center for Bone Marrow Transplantation, Laboratory of Stem Cells, National Cancer Institute (INCA), Rio de Janeiro 20230-130, RJ, Brazil

4. Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, RJ, Brazil

5. Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro 20230-130, RJ, Brazil

6. Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, ON, Canada

Abstract

Breast cancer treatment has advanced enormously in the last decade. Most of this is due to advances reached in the knowledge regarding tumor biology, mainly in the field of diagnosis and treatment. This review brings information about how the genomics-based information contributed to advances in breast cancer diagnosis and prognosis perspective, as well as presents how tumor biology discoveries fostered the main therapeutic approaches available to treat such patients, based on a personalized point of view.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

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