Opportunity for pharmacogenetics testing in patients with sickle cell anemia

Author:

Gallaway Katherine A1ORCID,Sakon Colleen2ORCID,Ongeri Jefney3,Patel Krina S3,Oliver Johnathan3,Patacca Heather3,O'Brien Andrew RW4,Skaar Todd C3,Tillman Emma M3ORCID

Affiliation:

1. Division of Pediatric Critical Care, Indiana University School of Medicine, Indianapolis, IN 46202, USA

2. Pharmacy Department, Indiana University Health, Indianapolis, IN 46202, USA

3. Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA

4. Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Abstract

Background: Patients with sickle cell disease (SCD) are exposed to numerous drugs over their lifespan, and many of these drugs have Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for personalized dosing. The authors' aim was to ascertain the number of drugs with CPIC guidelines prescribed to SCD patients. Materials & methods: A search of Indiana University Health affiliated hospitals' electronic medical record identified 957 patients with a diagnosis of SCD. Drugs or drug classes with CPIC actionable guidelines ordered as inpatient and outpatient prescriptions were collected from SCD patients. Results: During the 16-year period, 892 (93%) patients received at least one drug that could have been dosed according to CPIC guidelines. Conclusion: Preemptive pharmacogenetics testing should be considered in SCD patients in order to utilize these data throughout the patient's life.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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