Emerging role of the apelin system in cardiovascular homeostasis-Reference-Cited by-同舟云学术

Emerging role of the apelin system in cardiovascular homeostasis

Published:2007-06 Issue:1 Volume:1 Page:37-43
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Chong Kwok S¹,Gardner Roy S²,Ashley Euan A³,Dargie Henry J¹,McDonagh Theresa A⁴

Affiliation:

1. Western Infirmary, Department of Cardiology, Glasgow, UK.

2. Royal Infirmary, Department of Cardiology, Glasgow, UK.

3. Stanford University School of Medicine, Division of Cardiovascular Medicine, California, USA.

4. Royal Brompton Hospital, Department of Cardiology, UK.

Abstract

The angiotensin receptor-like 1 (APJ) and its novel ligand, apelin, share similarities in structure and anatomical distribution with that of angiotensin II and the angiotensin II type 1 receptor. However, apelin has positive inotropic, vasodilatory and diuretic properties. Differential expression and synthesis of apelin and the APJ receptor in normal and failing hearts suggest that the apelin system may contribute to the pathophysiology of human heart failure and has potential therapeutic use in treatment of heart failure.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/17520363.1.1.37

Reference49 articles.

1. The Cardiac Renin-Angiotensin System

2. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

3. Characterization of Apelin, the Ligand for the APJ Receptor

4. Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor

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