Beyond biologics: is there a role for systemic cytotoxic chemotherapy in neuroendocrine tumors?

Author:

Narayanan Sujata1,Kunz Pamela L1

Affiliation:

1. Stanford University School of Medicine, Stanford Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305–5826, USA

Abstract

Abstract:  Neuroendocrine tumors (NETs) are a group of biologically and clinically heterogeneous neoplasms that have varying degrees of responsiveness to systemic and targeted therapies. With recent advances in therapeutics, a number of biologic therapies have been incorporated into the management of NETs. In this review, we discuss the role of cytotoxic chemotherapy in the management of NETs with an overview of past and present clinical trials, current treatment guidelines and future directions.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Endocrinology,Oncology,Endocrinology, Diabetes and Metabolism

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