The role of osteoarthritis severity, BMI and age on clinical efficacy of bone marrow aspirate concentrate in the treatment of knee osteoarthritis-Reference-Cited by-同舟云学术

The role of osteoarthritis severity, BMI and age on clinical efficacy of bone marrow aspirate concentrate in the treatment of knee osteoarthritis

Published:2023-09 Issue:9 Volume:18 Page:735-747
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Rasovic Predrag¹^ORCID,Dulic Oliver¹^ORCID,Lalic Ivica²^ORCID,Matijevic Radmila¹^ORCID,Janjic Natasa¹^ORCID,Tosic Milan¹^ORCID,Aleksandric Dejan³^ORCID,Abazovic Dzihan⁴^ORCID,Miskulin Mladen⁵^ORCID,Matijevic Sara⁶^ORCID,Kovacevic Luka⁷^ORCID

Affiliation:

1. University of Novi Sad, Serbia, Medical Faculty, University Clinical Center of Vojvodina, Novi Sad, Serbia

2. University Business Academy in Novi Sad, Faculty Of Pharmacy, Novi Sad, Serbia

3. Institute for Orthopaedic Surgical Diseases “Banjica”, Belgrade, Serbia

4. BioCell General Hospital, Belgrade, Serbia

5. University of Split, Medical Faculty, Croatia

6. Big Data Institute, University of Oxford, UK

7. MRC Biostatistics Unit, University of Cambridge, UK

Abstract

Aim: The aim of this study was to assess whether BMI, severity of knee osteoarthritis, age and gender have any influence on the final clinical results of bone marrow aspirate concentrate injection. Method: A total of 111 study participants with painful knee osteoarthritis and different characteristics concerning before mentioned factors underwent bone marrow aspirate concentrate (BMAC) therapy and were followed up for 1 year. Result: Significant pain and functional improvement were observed in all participant groups. Participants' age and BMI did not influence the clinical outcome, but there was an influence of OA severity, especially among older patients. Conclusion: This study shows that BMAC therapy is effective. Younger patients with milder OA changes could be better candidates for long-lasting and more efficient BMAC therapy. Clinical Trial Registration: NCT03825133 ( ClinicalTrials.gov )

Funder

Provincial Government of Vojvodina, New technologies in Medicine,

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2023-0042

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1. Intra-articular injection of bone marrow aspirate concentrate (mesenchymal stem cells) in KL grade III and IV knee osteoarthritis: 4 year results of 37 knees;Scientific Reports;2024-02-01

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