Radioimmunotherapy-based conditioning regimen prior to autologous stem cell transplantation in non-Hodgkin lymphoma

Author:

Eskian Mahsa12,Khorasanizadeh MirHojjat12,Isidori Alessandro3,Rezaei Nima145

Affiliation:

1. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, 14194, Iran

2. Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran

3. Haematology & Haematopoietic Stem Cell Transplant Center, AORMN Marche Nord Hospital, Via Lombroso 1, 61122 Pesaro, Italy

4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

5. Cancer Immunology Project (CIP), Universal Scientific Education & Research Network (USERN), Tehran, Iran

Abstract

Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy and the sixth cause of death from cancer in the USA. Autologous stem cell transplantation (ASCT) is a potentially curative therapeutic option for many NHL patients. Choosing the most effective conditioning regimen prior to ASCT can lead to longer survival in these patients, and, as in many cases of high risk NHL, the only potentially curative option is stem cell transplantation. Radioimmunotherapy (RIT) is based on using radiolabeled monoclonal antibodies against tumoral antigens. Since lymphoma cells are sensitive to radiation, RIT has become a potential approach in treating NHL. In this review, we have discussed the efficacy and safety of RIT as an alternative conditioning regimen prior to ASCT.

Publisher

Future Medicine Ltd

Subject

Pharmacology (medical),Oncology,Hematology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Therapeutic options for rituximab-resistant patients;Resistance to Anti-Cd20 Antibodies and Approaches for their Reversal;2024

2. The role of transplantation in Hodgkin lymphoma;Frontiers in Oncology;2023-01-26

3. Dosimetric Approaches for Radioimmunotherapy of Non-Hodgkin Lymphoma in Myeloablative Setting;Seminars in Nuclear Medicine;2022-03

4. Novel Methods to Improve the Efficiency of Radioimmunotherapy for Non-Hodgkin Lymphoma;International Reviews of Immunology;2019-03-04

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