Association study of MUS81 gene polymorphisms and EBV-associated tumors in China

Abstract

Aim: Single nucleotide polymorphisms of MUS81 have been reported to be associated with several human tumors, but not with EBV infection. This study focused on identifying the relationship between MUS81 polymorphisms and EBV-associated tumors in China. Materials & methods: Three single nucleotide polymorphism loci of MUS81 were detected using the Sequenom MassARRAY technology. Results: The rs13817 genotype AA and allele A, rs648732 genotype TT and allele T were both significantly increased in EBV-associated gastric carcinoma (EBVaGC) than controls. Heterozygous TC of rs659857 was remarkably reduced in EBVaGC and EBV-associated nasopharyngeal carcinoma. Furthermore, significant differences were found between lymphoma and controls without an EBV association. Conclusion: Our findings indicated a strong relationship between MUS81 polymorphisms and the susceptibility to EBVaGC, EBV-associated nasopharyngeal carcinoma and lymphoma.