Nanomedicine as a potential novel therapeutic approach against the dengue virus

Author:

Zohra Tanzeel1ORCID,Saeed Faryal2,Ikram Aamer1,Khan Tariq3,Alam Siyab3,Adil Muhammad3,Gul Ayesha4,Almawash Saud5ORCID,Ayaz Muhammad6ORCID

Affiliation:

1. Public Health Laboratories Division, National Institute of Health, Islamabad, 45500, Pakistan

2. Department of Biotechnology, Quaid-i-Azam University, Islamabad, 45320, Pakistan

3. Department of Biotechnology, University of Malakand, University of Malakand, Chakdara, 18800 Dir (L), KP, Pakistan

4. Department of Chemical Engineering, Polytechnique Montreal, H3T IJ4, Canada

5. Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia

6. Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18800 Dir (L), KP, Pakistan

Abstract

Dengue is an arbovirus infection which is transmitted by Aedes mosquitoes. Its prompt detection and effective treatment is a global health challenge. Various nanoparticle-based vaccines have been formulated to present immunogen (antigens) to instigate an immune response or prevent virus spread, but no specific treatment has been devised. This review explores the role of nanomedicine-based therapeutic agents against dengue virus, taking into consideration the applicable dengue virus assays that are sensitive, specific, have a short turnaround time and are inexpensive. Various kinds of metallic, polymeric and lipid nanoparticles with safe and effective profiles present an alternative strategy that could provide a better remedy for eradicating the dengue virus.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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