Engineered nanomedicines for augmenting the efficacy of colorectal cancer immunotherapy-Reference-Cited by-同舟云学术

Engineered nanomedicines for augmenting the efficacy of colorectal cancer immunotherapy

Published:2022-09 Issue:22 Volume:17 Page:1721-1745
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Abdelgalil Riham M¹²^ORCID,Elmorshedy Yomna M¹²^ORCID,Elkhodairy Kadria A¹²^ORCID,Teleb Mohamed²³^ORCID,Bekhit Adnan A²³⁴^ORCID,Khattab Sherine N⁵^ORCID,Elzoghby Ahmed O¹²⁶^ORCID

Affiliation:

1. Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, 21521, Alexandria, Egypt

2. Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, 21521, Alexandria, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 21521, Alexandria, Egypt

4. Pharmacy Program, Allied Health Department, College of Health & Sport Sciences, University of Bahrain, 32038, Riffa, Kingdom of Bahrain

5. Chemistry Department, Faculty of Science, Alexandria University, 21521, Alexandria, Egypt

6. Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, MA 02115, Boston, USA

Abstract

Colorectal cancer (CRC) is one of the most devastating diseases worldwide. Immunotherapeutic agents for CRC treatment have shown limited efficacy due to the immunosuppressive tumor microenvironment (TME). In this context, various types of nanoparticles (NPs) have been used to reverse the immunosuppressive TME, potentiate the effect of immunotherapeutic agents and reduce their systemic side effects. Many advantages could be offered by NPs, related to drug-loading efficiency, particle size and others that can potentially aid the delivery of immunotherapeutic agents. The recent research on how nano-based immunotherapy can remodel the immunosuppressive TME of CRC and hence boost the antitumor immune response, as well as the challenges that face clinical translation of NPs and future perspectives, are summarized in this review article.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2022-0214

Reference160 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

3. Tumor immune microenvironment and nano-immunotherapeutics in colorectal cancer

4. Cancer immunotherapy comes of age

5. Nano-immunotherapy: Unique mechanisms of nanomaterials in synergizing cancer immunotherapy