Theranostic nanoemulsions: codelivery of hydrophobic drug and hydrophilic imaging probe for cancer therapy and imaging

Author:

Yang Xinggang1,Wang Dun2,Ma Yan3,Zhao Qiang4,Fallon John K5,Liu Dan2,Xu Xian Emma5,Wang Yongjun1,He Zhonggui1,Liu Feng5

Affiliation:

1. School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang, 110016, China

2. Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road, Shenyang, 110016, China

3. School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Waihuan Eastern Road, Guangzhou, 510006, China

4. College of Chemical Engineering, Sichuan University, No.24 South Section 1, Yihuan Road, Chengdu, 610065, China

5. Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7571, USA

Abstract

Aim: To develop a theranostic nanoemulsion (TNE) that can codeliver the conjugates of a hydrophobic drug paclitaxel (PTX) and a hydrophilic imaging probe sulforhodamine B (SRB). Materials & methods: The TNE was established using core-matched technology, and can achieve high encapsulation efficiency and synchronized release of the loaded cargo. It has been examined for a correlation between the dynamic uptake of PTX and the intensity of SRB imaging signal in different organs. Results & discussion: Our data demonstrate that the TNE, with improved circulation time, increases therapeutic efficacy and imaging efficiency in both drug-sensitive and drug-resistant cancer. The TNE could not satisfy the demand of visual diagnosis in the living animal because of interference. We therefore formulated a long-circulating theranostic nanoemulsion (LCTNE). Results showed that the LCTNE can meet imaging requirements in vivo. Conclusion: The LCTNE plays a good therapeutic and diagnostic role for subcutaneous tumors in the living animal.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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