Functional gold nanoparticles as photothermal agents for selective-killing of pathogenic bacteria

Author:

Huang Wei-Chieh1,Tsai Pei-Jane2,Chen Yu-Chie13

Affiliation:

1. National Chiao Tung University, Department of Applied Chemistry, Hsinchu 300, Taiwan.

2. Tzu Chi University, Department of Laboratory Medicine and Biotechnology, Hualien 970, Taiwan

3. National Chiao Tung University, Institute of Molecular Science, Hsinchu 300, Taiwan

Abstract

Aims: Our aim was to demonstrate that functional gold nanoparticles can be used as photothermal agents for the selective killing of pathogenic bacteria. Materials & methods: Gold nanoparticles with polygonal shapes, capable of absorbing near infrared (NIR) light, were generated through a photochemical reaction. Vancomycin, which can bind with the terminal D-Ala-D-Ala moieties of the peptide units of pathogen cell walls, was immobilized on the surface of the gold nanoparticles. The vancomycin-bound gold nanoparticles were used as the photothermal agents for the inhibition of pathogenic bacteria growth, under irradiation of NIR light (808 nm). Results & discussion: We have demonstrated that vancomycin-bound gold nanoparticles are capable of selective-binding onto the cell walls of pathogenic bacteria. A large portion (>99%) of bacteria targeted by the gold nanoparticles was destroyed under illumination by NIR light within 5 min owing to suffering from heating. Conclusions: This photothermal approach is effective for the inhibition of pathogenic bacteria cell growth, including Gram-positive bacteria, Gram-negative bacteria and antibiotic-resistant bacteria.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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