Mimicking nature’s nanocarrier: synthetic low-density lipoprotein-like nanoparticles for cancer-drug delivery

Author:

Corbin Ian R1,Zheng Gang1

Affiliation:

1. Ontario Cancer Institute and University of Toronto, MaRS Center, TMDT 5–363, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

Abstract

Evaluation of: Nikanjam M, Blakely EA, Bjornstad KA, Shu X, Budinger TF, Forte TK: Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme. Int. J. Pharm. 3287, 86–94 (2007) [1] . Low-density lipoproteins have long been recognized as a viable nanocarrier for targeted delivery of drug and imaging agents. Many groups have published promising initial findings; however, progress in this field has been impeded by the need to isolate low-density lipoproteins from fresh donor plasma. In a recent paper by Nikanjam and colleagues, synthetic low-density lipoprotein-like nanoparticles were prepared from commercial lipids and a bifunctional synthetic peptide containing the low-density lipoprotein receptor-binding domain and the lipid-binding motif. These particles were shown to behave similarly to native low-density lipoproteins and also to bind to the low-density lipoprotein receptor on cancer cells. Herein, we evaluate the utility of this novel delivery vehicle and discuss what role this technology may have in nanomedicine.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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