Affiliation:
1. SAIC-Frederick Inc., Nanotechnology Characterization Laboratory, Advanced Technology Program, NCI-Frederick, 1050 Boyles St., Bldg. 469, Frederick MD, 21702, USA.
Abstract
Nanotechnology offers many advantages to traditional drug design, delivery and medical diagnostics; however, nanomedicines present considerable challenges for preclinical development. Nanoparticle constructs intended for medical applications consist of a wide variety of materials, and their small size, unique physicochemical properties and biological activity often require modification of standard characterization techniques. A rational characterization strategy for nanomedicines includes physicochemical characterization, sterility and pyrogenicity assessment, biodistribution (absorption, distribution, metabolism and excretion [ADME]) and toxicity characterization, which includes both in vitro tests and in vivo animal studies. Here, we highlight progress for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy.
Subject
Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering
Cited by
323 articles.
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