Impact of smoking on lung cancer treatment effectiveness: a review

Author:

Condoluci Adalgisa1,Mazzara Calogero2,Zoccoli Alice2,Pezzuto Aldo3,Tonini Giuseppe2

Affiliation:

1. Thoracic Surgery Unit, San Giovanni Hospital, Bellinzona, Switzerland

2. Department of Oncology, University Campus Bio-Medico of Rome, Rome, Italy

3. Cardiovascular & Pulmonary Department, Sant'Andrea Hospital, Sapienza University, Rome, Italy

Abstract

Tobacco smoke contains more than 4000 detectable substances, such as polycyclic aromatic hydrocarbons, nicotine, carbon monoxide and heavy metals, which are considered powerful enzymatic inducers that have notable influence on the efficacy and tolerability of many medications through complex pharmacokinetic and pharmacodynamic interactions. As a result, adjustments of drug dosages are required in smokers, both if they continue to smoke or if they quit after smoking cessation treatment. The purpose of this review is to examine the main drug interactions with tobacco smoke clinically relevant, with a closer look on patients developing oncologic diseases.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Reference75 articles.

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