Evaluation of rapid antigen detection kits for the detection of SARS-CoV-2 B.1.617.2 virus-Reference-Cited by-同舟云学术

Evaluation of rapid antigen detection kits for the detection of SARS-CoV-2 B.1.617.2 virus

Published:2022-06 Issue:6 Volume:17 Page:387-392
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Mak Gannon CK¹^ORCID,Lau Stephen SY¹,Wong Kitty KY¹,Chow Nancy LS¹,Lau Chi-Shan¹,Lam Edman TK¹,Ng Ken HL¹,Chan Rickjason CW¹

Affiliation:

1. Microbiology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China

Abstract

Aim: Currently, there is lack of data regarding rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.617.2 virus. Objective: The purpose of this evaluation is to assess analytical sensitivity of 12 RAD kits against SARS-CoV-2 B.1.617.2. Study design: Analytical sensitivity was determined by limit of detection (LOD). A serial tenfold dilution set from a respiratory specimen collected from a COVID-19 patient infected by SARS-CoV-2 B.1.617.2 was used. RT-PCR was used as a reference method. Results: The LOD results showed that 11 and one RAD kits were 100- and 1000-fold less sensitive than RT-PCR respectively. Conclusion: The results showed that the RAD kits evaluated in this study may be used for first-line screening of the SARS-CoV-2 B.1.617.2 variant.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2021-0229

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