A brief review on DNA vaccines in the era of COVID-19-Reference-Cited by-同舟云学术

A brief review on DNA vaccines in the era of COVID-19

Published:2022-01 Issue:1 Volume:17 Page:49-66
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Shafaati Maryam¹^ORCID,Saidijam Massoud²³^ORCID,Soleimani Meysam⁴^ORCID,Hazrati Fereshte⁴,Mirzaei Rasoul⁵^ORCID,Amirheidari Bagher⁶⁷^ORCID,Tanzadehpanah Hamid²³^ORCID,Karampoor Sajad⁸^ORCID,Kazemi Sima⁵,Yavari Bahram²³^ORCID,Mahaki Hanie⁹^ORCID,Safaei Mohsen¹⁰,Rahbarizadeh Fatemeh¹¹^ORCID,Samadi Pouria²³^ORCID,Ahmadyousefi Yaghoub²³^ORCID

Affiliation:

1. Department of Microbiology, Faculty of Sciences, Jahrom Branch, Islamic Azad University, Jahrom, Iran

2. Department of Medical Biotechnology, School of Advanced Medical Sciences & Technologies, Hamadan University of Medical Sciences, Hamadan, Iran

3. Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

4. Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

5. Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

6. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

7. Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran

8. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

9. Vascular & Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

10. Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran

11. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Abstract

This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design strategies are described, then specific issues related to the industrial production of DNA vaccines are discussed, including the production and purification of DNA products such as plasmid DNA, minicircle DNA, minimalistic, immunologically defined gene expression (MIDGE) and Doggybone™. The use of adjuvants to enhance the immunogenicity of DNA vaccines is then discussed. In addition, different delivery routes and several physical and chemical methods to increase the efficacy of DNA delivery into cells are explained. Recent preclinical and clinical trials of DNA vaccines for COVID-19 are then summarized. Lastly, the advantages and obstacles of DNA vaccines are discussed.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2021-0170

Reference127 articles.

1. COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response

2. Nucleic acid aptamers in diagnosis of colorectal cancer

3. DNA vaccines: prime time is now

4. Direct Gene Transfer into Mouse Muscle in Vivo

5. Safety and efficacy of DNA vaccines

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