Enhanced activity of NLRP3 inflammasome and its proinflammatory effect in influenza A viral pneumonia-Reference-Cited by-同舟云学术

Enhanced activity of NLRP3 inflammasome and its proinflammatory effect in influenza A viral pneumonia

Published:2023-01 Issue:1 Volume:18 Page:21-30
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Shi Xiaohan¹²^ORCID,Wu Benquan¹²^ORCID,Chen Junxian¹²,Luo Jinmei¹²^ORCID,Li Mei³,Jiang ZhenYou⁴,Shi Yunfeng¹²^ORCID

Affiliation:

1. Department of MICU, Department of Respiratory & Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China

2. Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou, PR China

3. VIP Healthcare Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China

4. Department of Microbiology & Immunology, Basic Medical College, Jinan University, Guangzhou, PR China

Abstract

Aim: The aim of this study was to investigate the activity of NLRP3 inflammasome and its effect on inducing severe pneumonia 1 week after influenza A virus (IAV) infection. Materials & methods: The expression levels of NLRP3, caspase-1 and IL-1β were assessed in murine macrophages stimulated with IAV. And the severity of viral pneumonia in mice was explored. Results & conclusion: The data showed that although the expression of NLRP3 diverged, activity of NLRP3 inflammasome was enhanced 1 week after IAV infection, and more severe viral pneumonia was associated with IL-1β in serum. It infers that enhanced activity of NLRP3 inflammasome induces augmented expression of IL-1β and severe pneumonia in a NLRP3-independent way, 1 week after IAV infection.

Funder

Science and Technology Program of Guangdong Province, China

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2021-0025

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