Corpus callosum in aging and neurodegenerative diseases

Abstract

SUMMARY The corpus callosum (CC) is a major white matter bundle that connects primarily homologous areas of the cortex. The structure may be involved in interhemispheric communication and enable the lateralization of certain cerebral functions. Despite its possible role as the main conduit for interhemispheric communication, interest from researchers has, at times, been sparse. Renewed interest has led to research that has shown that the CC may play a role in both cognitive aging and neurodegenerative diseases including Alzheimer´s disease and frontotemporal dementia. Studies employing structural MRI and diffusion-weighted MRI have found distinct subregional patterns of callosal atrophy in aging, Alzheimer´s disease and frontotemporal dementia. Furthermore, imaging studies may help to elucidate the underlying pathological mechanisms of callosal atrophy. The present review aims to provide an overview of the current knowledge of the structure and function of the CC and its role in aging and neurodegenerative disease.