Temozolomide rechallenge in recurrent glioblastoma: when is it useful?

Author:

Franceschi Enrico1,Lamberti Giuseppe1,Visani Michela2,Paccapelo Alexandro1,Mura Antonella1,Tallini Giovanni2,Pession Annalisa3,De Biase Dario3,Minichillo Santino1,Tosoni Alicia1,Di Battista Monica1,Cubeddu Alessio1,Bartolini Stefania1,Brandes Alba A1

Affiliation:

1. Department of Medical Oncology, Bellaria–Maggiore Hospitals, Azienda USL, IRCCS Institute of Neurological Sciences, Bologna, Italy

2. Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy

3. Department of Pharmacy & Biotechnology (Dipartimento di Farmacia e Biotecnologie) – Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy

Abstract

Aim: To identify patients with recurrent glioblastoma after temozolomide (TMZ) concurrent with and adjuvant to radiotherapy who could benefit from TMZ rechallenge at the time of disease progression. Methods: We retrospectively evaluated 106 glioblastoma patients who had nonprogressive disease at first magnetic resonance imaging after completion of TMZ concurrent with and adjuvant to radiotherapy, a treatment-free interval (TFI) of at least 8 weeks and received TMZ rechallenge or a nitrosourea at the time of progression. Results: In patients with TFI ≥5 months, median survival was 17.7 and 11.6 months and median progression-free survival was 8.1 and 5.8 months in the TMZ and nitrosourea group, respectively. Longer TFI was associated with reduced risk for death (p = 0.002) and for disease progression (p = 0.005). Conclusion: TFI ≥5 months represents a predictor of retained TMZ sensitivity.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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