Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders

Author:

Khanna Rajesh1,Wilson Sarah M2,Brittain Joel M2,Weimer Jill3,Sultana Rukhsana4,Butterfield Allan4,Hensley Kenneth5

Affiliation:

1. Departments of Pharmacology & Toxicology, Indianapolis, IN 46202, USA.

2. Program in Medical Neurosciences, Paul & Carole Stark Neurosciences Research Institute Indianapolis, IN 46202, USA

3. Sanford Children’s Health Research Center, Sanford Research & Department of Pediatrics, Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD 57104, USA

4. Department of Chemistry, Center of Membrane Sciences, & Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA

5. Department of Pathology & Department of Neurosciences, University of Toledo Medical Center, Toledo, OH 43614, USA

Abstract

CRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein that mediates axon/dendrite specification and axonal growth. Mapping the CRMP2 interactome has revealed previously unappreciated functions subserved by this protein. Together with its canonical roles in neurite growth and retraction and kinesin-dependent axonal transport, it is now known that CRMP2 interacts with numerous binding partners to affect microtubule dynamics; protein endocytosis and vesicular cycling, synaptic assembly, calcium channel regulation and neurotransmitter release. CRMP2 signaling is regulated by post-translational modifications, including glycosylation, oxidation, proteolysis and phosphorylation; the latter being a fulcrum of CRMP2 functions. Here, the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders are discussed and evidence is presented for therapeutic strategies targeting CRMP2 functions.

Publisher

Future Medicine Ltd

Subject

Neurology (clinical),Neurology

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