Evaluation of HSP70 levels in ectopic pregnancy, abortus imminens and intrauterine pregnancy-Reference-Cited by-同舟云学术

Evaluation of HSP70 levels in ectopic pregnancy, abortus imminens and intrauterine pregnancy

Published:2022-12 Issue:18 Volume:16 Page:1251-1258
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Yıldız Şükrü¹^ORCID,Karakaş Sema¹^ORCID,Kaya Cihan²^ORCID,Kural Alev³^ORCID,Gedikbaşı Asuman⁴^ORCID,Ekin Deniz⁵^ORCID,Serhanoğlu Zınar¹^ORCID,Çaypınar Sema S⁶^ORCID,Ekin Murat¹^ORCID

Affiliation:

1. University of Health Sciences Istanbul, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, Department of Obstetrics & Gynecology, Istanbul, 34180, Turkey

2. Acıbadem Mehmet Ali Aydınlar University, Department of Obstetrics & Gynecology, Acıbadem Bakirkoy Hospital, Istanbul, 34200, Turkey

3. University of Health Sciences Istanbul, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, Department of Biochemistry, Istanbul, 34180, Turkey

4. Institute of Child Health, Istanbul University Faculty of Medicine, Istanbul, 34200, Turkey

5. University of Bristol, Faculty of Life Sciences, Bristol, BS8 1TH, United Kingdom

6. University of Health Sciences Istanbul, Başakşehir Çam ve Sakura Training & Research Hospital, Department of Perinatology, Istanbul, 34280, Turkey

Abstract

Aim: To assess the serum levels of HSP70 concentrations in ectopic pregnancy (EP) patients compared with abortus imminens (AI) patients and healthy controls. Materials & methods: Age-matched patients were divided into three groups, with 30 patients in each group: EP, AI and healthy intrauterine pregnancy groups. Blood samples were taken from the antecubital vein and kept for HSP70 analysis. Results: The HSP70 levels were higher in the EP group than in AI patients and healthy controls (p < 0.05). The area under the curve for the serum HSP70 assay reached a value of 0.81 for a cutoff point of 11.12 pg/ml, which identified women with EP. Conclusion: Serum HSP70 levels increased in women with EP compared with healthy controls and women with AI.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2022-0550

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