GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension-Reference-Cited by-同舟云学术

GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension

Published:2022-12 Issue:17 Volume:16 Page:1193-1207
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Keranov Stanislav¹²^ORCID,Widmann Laila¹,Jafari Leili³,Liebetrau Christoph⁴,Keller Till¹²³^ORCID,Troidl Christian²³,Kriechbaum Steffen²³,Voss Sandra²³,Bauer Pascal¹,Richter Manuel J⁵,Tello Khodr⁵,Gall Henning⁵,Ghofrani Hossein A⁵,Wiedenroth Christoph B⁶,Guth Stefan⁶,Seeger Werner⁵,Hamm Christian W¹²³,Nef Holger¹²,Dörr Oliver¹²

Affiliation:

1. Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany

2. German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany

3. Department of Cardiology, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany

4. Cardioangiological Center Bethanien (CCB), Frankfurt, 60389, Germany

5. Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen & Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, 35392, Germany

6. Department of Thoracic Surgery, Kerckhoff Heart & Lung Center, Bad Nauheim, 61231, Germany

Abstract

Background: This study analyzed the utility of soluble ST2 (sST2) and GDF-15 as biomarkers of right ventricular (RV) function in patients with pulmonary hypertension (PH). Methods: GDF-15 and sST2 serum concentrations were measured in patients with PH (n = 628), dilated cardiomyopathy (n = 31) and left ventricular hypertrophy (n = 47), and in healthy controls (n = 61). Results: Median sST2 and GDF-15 levels in patients with left ventricular hypertrophy were higher than in patients with PH and dilated cardiomyopathy. In tertile analysis GDF-15 >1363 pg/ml and sST2 >38 ng/ml were associated with higher N-terminal pro-brain natriuretic peptide, RV systolic dysfunction, RV-pulmonary arterial uncoupling and hemodynamic impairment. Conclusion: GDF-15 and sST2 are potential biomarkers of RV dysfunction in patients with PH.

Funder

Collaborative Research Center 1213 Pulmonary Hypertension and Cor Pulmonale, German Research Foundation

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2022-0395

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