Prognostic impact of cardiohepatic syndrome in patients with ST-segment elevation myocardial infarction

Author:

Sungur Mustafa A1ORCID,Sungur Aylin2ORCID,Karagöz Ali3ORCID,Can Fatma1ORCID,Yılmaz Mehmet F1ORCID,Zeren Gönül1ORCID,Avcı İlhan İ1ORCID,Yumurtaş Ahmet Ç1ORCID,Tanboğa İbrahim H4ORCID,Karabay Can Y1ORCID

Affiliation:

1. Department of Cardiology, Dr. Siyami Ersek Thoracic & Cardiovascular Surgery Education Research Hospital, Selimiye Mh. Tıbbiye Cd. No: 25 Üsküdar, İstanbul, Turkey

2. Department of Cardiology, Süreyyapaşa Chest Diseases & Thoracic Surgery Training & Research Hospital, Başıbüyük Mh. Süreyyapaşa Yerleşkesi, Maltepe, İstanbul, Turkey

3. Department of Cardiology, Kartal Koşuyolu Heart Training & Research Hospital,Denizer Cd. Cevizli Kavşağı No: 2 Kartal, İstanbul, Turkey

4. Department of Cardiology, Nisantası University, Saray Mh. Site Yolu Cd. No: 7, Ümraniye, İstanbul, Turkey

Abstract

Background: Cardiohepatic syndrome (CHS) indicates a bidirectional interaction between the heart and liver. This study was designed to evaluate the impact of CHS on in-hospital and long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention. Materials & methods: 1541 consecutive STEMI patients were examined. CHS was defined as the elevation of at least two of three cholestatic liver enzymes: total bilirubin, alkaline phosphatase and gamma-glutamyl transferase. Results: CHS was present in 144 (9.34%) patients. Multivariate analyses revealed CHS as an independent predictor of in-hospital (odds ratio: 2.48; 95% CI: 1.42–4.34; p = 0.001) and long-term mortality (hazard ratio: 2.4; 95% CI: 1.79–3.22; p < 0.001). Conclusion: The presence of CHS is a predictor of poor prognosis in patients with STEMI and should be evaluated during the risk stratification of these patients.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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