Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling

Author:

Wang Jiaqi1,Zhang Dandan2,Zhu Ying3ORCID,Mo Xiumei4,McHugh Patrick C5,Tong Qiang6

Affiliation:

1. Clinical Research Center, Changhai Hospital, Shanghai, 200433, China

2. Arachna Skin Biotechnology Center, Eston Cell Technology (Shanghai) Co. Ltd, Shanghai, 201611, China

3. Department of Respiratory & Critical Care Medicine, Seventh Medical Center of Chinese PLA General Hospital, Beijing, 100700, China

4. Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China

5. Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, HD1 3DH, UK

6. Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200235, China

Abstract

Background: Skin regeneration from an injury without a scar is still a challenge. Methods: A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of mesenchymal stem cells (MSCs). CD11b+ and CD45 macrophages were detected and levels of cytokines were tested. Results: The expression of growth factors VEGF, FGF2 and EGF was elevated after treatment administered to MSCs. The administration of ethanolic extract of astragalus decreased the expression of TNF-α, IL-1β and IL-6 and simultaneously increased the levels of IL-10. The combination sped up the process of wound healing. A sustained-release gel with both ingredients was developed to enhance restoration from granulation. Conclusion: The extract of astragalus promotes the efficacy of MSC-derived exosomes in skin repair.

Funder

National Natural Science Foundation of China

Shanghai Municipal Health Commission

Major project of Eighth Medical Center of Chinese PLA General Hospital

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

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