Anxiety and verbal memory performance in APOE-4 carriers and noncarriers aged 50 years and above

Author:

Curiel Ashley R12,Miller Karen J1,Pollard Karen3,Kim Jeanne4,Kravitz Jena5,Small Gary W1

Affiliation:

1. University of California, Los Angeles, Semel Institute, 760 Westwood Plaza, Los Angeles, CA 90095, USA; UCLA Longevity Center, Peter V Ueberroth Building, 10945 Le Conte Avenue, Suite 3119, Los Angeles, CA 90095-6980, USA.

2. Pepperdine University, 24255 Pacific Coast Highway, Malibu, CA 90263, USA

3. University of Virginia, Charlottesville, VA, USA

4. Casa Colina Centers for Rehabilitation, 255 East Bonita Avenue, Pomona, CA 91767, USA

5. Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA

Abstract

Aims: The current study sought to explore the relationship between state and trait anxiety and delayed verbal memory performance in APOE-4 carriers and noncarriers who were aged 50 years and above. Materials & methods: The study was a retrospective analysis of 267 participants aged 50 years and above who had completed genetic testing for APOE status, the State-Trait Anxiety Inventory, and a comprehensive neuropsychological battery that included three delayed verbal memory measures (Wechsler Memory Scale – 3rd Edition, Logical Memory and Verbal Pairs subtests and the Buschke Selective Reminding Test). Results: An inverse relationship was found between state anxiety and delayed verbal memory performance. No difference in level of anxiety was found between APOE-4 carriers versus noncarriers. Conclusion: State anxiety, but not trait anxiety, was found to have an inverse relationship with delayed verbal memory performance. For example, as self-reported state anxiety increased, delayed verbal memory scores decreased. This relationship did not appear to be influenced by the presence or absence of the APOE-4 allele.

Publisher

Future Medicine Ltd

Subject

Geriatrics and Gerontology,General Medicine

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