Usual opioid dosing does not adversely affect the course of healthcare-associated Clostridioides difficile infection-Reference-Cited by-同舟云学术

Usual opioid dosing does not adversely affect the course of healthcare-associated Clostridioides difficile infection

Published:2021-03 Issue:2 Volume:11 Page:151-157
ISSN:1758-1869
Container-title:Pain Management
language:en
Short-container-title:Pain Management

Author:

Chowdhry Monica¹,Haden Douglas²,Kemper Suzanne¹,Helmick Kristen¹,Kawsara Muhammad³,Huggett Ashley⁴,Stark Andrea¹,Khan Ahmad¹,Shah Muhammad⁵,Bhaty Mustafa⁶,Farooq Junaid¹,Singh Shailendra¹,McJunkin Brittain¹^ORCID

Affiliation:

1. West Virginia University Health Sciences Center, Charleston Division/Charleston Area Medical Center, Charleston, WV 25304, USA

2. Department of Critical Care/Pulmonary Disease, Atrium Health’s Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA

3. Department of Internal Medicine, West Virginia University Health Sciences Center, Morgantown, 1 Medical Center Drive, Morgantown, WV 26505, USA

4. Department of Internal Medicine, Prisma Health/University of South Carolina School of Medicine, 2 Medical Park, Columbia, SC 29203, USA

5. Addiction Science Center, University of Cincinnati Medical Center, 3132 Harvey Ave., Cincinnati, OH 45239, USA

6. Department of Internal Medicine, Southside Regional Medical Center, 200 Medical Park Blvd. Petersburg, VA 23805, USA

Abstract

Aim: We sought to determine if opioid exposure may have a detrimental effect on the course of Clostridioides difficile infection (CDI). Materials & methods: We compared opioid exposure in patients with well-defined severe CDI and non-severe CDI. Results: Following exclusions, 403 records were reviewed. Of this group, 128/403 (31.7%) were determined to have severe CDI by strict criteria, and 275/403 (68.3%) were found to have non-severe CDI. Full multivariate regression and reduced model of potential predictors for severe CDI showed no association with opioids prescribed. Conclusion: Opioid exposure (predominantly in modest range) does not appear to be a risk factor for severe healthcare-associated CDI.

Publisher

Future Medicine Ltd

Subject

General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pmt-2020-0066

Reference24 articles.

1. Changes in Prevalence of Health Care–Associated Infections in U.S. Hospitals

2. Current Trends in the Epidemiology and Outcomes of Clostridium difficile Infection

3. Burden ofClostridium difficileInfection in the United States

4. Cost of hospital management of Clostridium difficile infection in United States—a meta-analysis and modelling study

5. Risk factors for Clostridium difficile infections – an overview of the evidence base and challenges in data synthesis