Management of metastatic ovarian Sertoli–Leydig cell tumor with sporadic multinodular goiter: a case report and literature review

Abstract

Information regarding treatment for patients with metastatic ovarian Sertoli–Leydig cell tumor (SLCT) has been extremely limited. We report a young woman whose stage IA, poorly differentiated SLCT was initially managed surgically 9 months earlier, and who presented with extensively metastatic SLCT. She had a dramatic response to the combination of bleomycin, etoposide and cisplatin followed by stem cell transplantation and surgery, and has shown no evidence of disease recurrence for 8 months postoperatively. The patient was also found to have sporadic non-toxic multinodular goiter, which has not changed over the treatment course as mentioned. A review of the literature concerning the management of metastatic ovarian SLCT, along with its coexistence with multinodular goiter, is presented.