Managing relapsing–remitting multiple sclerosis following first drug failure

Abstract

SUMMARY IFN-β and glatiramer acetate are the usual first-line treatments for cases of relapsing–remitting multiple sclerosis. As both of these agents are only partially effective in controlling disease activity, ‘breakthrough’ disease is common. Deciding how much breakthrough constitutes a treatment failure necessitating a switch in therapy is now a common problem that most clinicians will encounter in practice. In this article we will discuss the approach to deciding when treatment failure occurs and the strategies that can be used to tackle this problem.