Decoding mitochondrial–nuclear (epi)genome interactions: the emerging role of ncRNAs

Author:

Nguyen Julia1ORCID,Le Quinn1ORCID,Win Phyo W1ORCID,Hill Kathleen A2ORCID,Singh Shiva M23ORCID,Castellani Christina A1435ORCID

Affiliation:

1. Department of Pathology & Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 3K7, Canada

2. Department of Biology, Western University, London, ON, N6A 3K7, Canada

3. Children's Health Research Institute, Lawson Research Institute, London, ON, N6C 2R5, Canada

4. Department of Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 3K7, Canada

5. McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Abstract

Bidirectional communication between the mitochondria and the nucleus is required for several physiological processes, and the nuclear epigenome is a key mediator of this relationship. ncRNAs are an emerging area of discussion for their roles in cellular function and regulation. In this review, we highlight the role of mitochondrial-encoded ncRNAs as mediators of communication between the mitochondria and the nuclear genome. We focus primarily on retrograde signaling, a process in which the mitochondrion relays ncRNAs to translate environmental stress signals to changes in nuclear gene expression, with implications on stress responses that may include disease(s). Other biological roles of mitochondrial-encoded ncRNAs, such as mitochondrial import of proteins and regulation of cell signaling, will also be discussed.

Funder

Western University

Government of Ontario

Natural Sciences and Engineering Research Council of Canada

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

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