The role of EZH2 in ocular diseases: a narrative review-Reference-Cited by-同舟云学术

The role of EZH2 in ocular diseases: a narrative review

Published:2023-05 Issue:9 Volume:15 Page:557-570
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Peng Yu¹,Bui Christine HT¹,Zhang Xiu J¹,Chen Jian S²³⁴,Tham Clement C¹⁵⁶⁷,Chu Wai K¹⁷,Chen Li J¹⁶⁷,Pang Chi P¹⁷,Yam Jason C¹⁵⁸⁶⁷^ORCID

Affiliation:

1. Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, 999077, Hong Kong

2. Aier School of Ophthalmology, Central South University, Changsha, Hunan Province, 410000, China

3. Aier Eye Institute, Changsha, Hunan Province, 410000, China

4. Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, Guangdong Province, 510000, China

5. Hong Kong Eye Hospital, Kowloon, 999077, Hong Kong

6. Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital, 999077, Hong Kong

7. Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, 999077, Hong Kong

8. Department of Ophthalmology, Hong Kong Children’s Hospital, 999077, Hong Kong

Abstract

EZH2, acting as a catalytic subunit of PRC2 to catalyze lysine 27 in histone H3, induces the suppression of gene expression. EZH2 can regulate cell proliferation and differentiation of retinal progenitors, which are required for physiological retinal development. Meanwhile, an abnormal level of EZH2 has been observed in ocular tumors and other pathological tissues. This review summarizes the current knowledge on EZH2 in retinal development and ocular diseases, including inherited retinal diseases, ocular tumors, corneal injury, cataract, glaucoma, diabetic retinopathy and age-related retinal degeneration. We highlight the potential of targeting EZH2 as a precision therapeutic target in ocular diseases.

Funder

CUHK Jockey Club Children's Eye Care Programme

the CUHK Jockey Club Myopia Prevention Programme

Health and Medical Research Fund

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2023-0147

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