SIX4, a potential therapeutic target for estrogen receptor-positive breast cancer patients, is associated with low promoter methylation level

Author:

Wu Hua-Tao12ORCID,Wu Zheng34ORCID,Hou Yan-Yu34,Fang Ze-Xuan34,Wu Bing-Xuan12,Deng Yu12,Cui Yu-Kun2,Liu Jing34ORCID

Affiliation:

1. Department of General Surgery, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China

2. Laboratory for Diagnosis & Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China

3. The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China

4. Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou, 515041, China

Abstract

Aim: To investigate SIX4 in breast cancer. Methods: Publicly available online tools were used to analyze the expression, methylation and prognostic significance of SIX4 in breast cancer, as well as its immunohistochemistry. Results: High SIX4 levels were associated with low SIX4 promoter methylation, especially in estrogen receptor-positive breast cancer. Increased SIX4 was related to advanced stage and decreased immune infiltration. Gene set enrichment analysis found that the SIX4-correlated genes were enriched in transcriptional processing and immune response. Patients with high SIX4 expression tended to have poor survival, especially those with estrogen receptor-positive breast cancer. Conclusion: High SIX4 expression in breast cancer plays an oncogenic role, promoting the development of malignancies through suppressing the immune response, especially in luminal subtypes, and is associated with a low promoter methylation level.

Funder

National Natural Science Foundation of China

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

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