Clinically informative microRNAs for SARS-CoV-2 infection-Reference-Cited by-同舟云学术

Clinically informative microRNAs for SARS-CoV-2 infection

Published:2023-07 Issue:13 Volume:15 Page:705-716
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Ergün Sercan¹²^ORCID,Sankaranarayanan Ramamoorthy³^ORCID,Petrović Nina⁴⁵^ORCID

Affiliation:

1. Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

2. Department of Multidisciplinary Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey

3. Department of Plant Sciences, School of Biological Sciences, Madurai Kamaraj University, Tamil Nadu, India

4. Laboratory for Radiobiology & Molecular Genetics, Department of Health & Environment, ‘VINČA’ Institute of Nuclear Sciences – National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12–14, Belgrade, 11001, Serbia

5. Department of Experimental Oncology, Institute for Oncology & Radiology of Serbia, Pasterova 14, Belgrade, 11000, Serbia

Abstract

COVID-19 is a viral respiratory infection induced by the newly discovered coronavirus SARS-CoV-2. miRNA is an example of a strong and direct regulator of a gene’s transcriptional activity. The interaction between miRNAs and their target molecules is responsible for homeostasis. Virus-derived and host-derived miRNAs are involved in the activity of hiding from immune system cells, inducing the inflammatory reaction through interplay with associated genes, during SARS-COV-2 infection. Interest in miRNAs has raised the comprehension of the machinery and pathophysiology of SARS-COV-2 infection. In this review, the effects and biological roles of miRNAs on SARS-CoV-2 pathogenicity and life cycle are described. The therapeutic potential of miRNAs against SARS-CoV-2 infection are also mentioned.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2023-0179

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