COVID-19 and cancer: insights into their association and influence on genetic and epigenetic landscape

Author:

Ghosh Mrinal K1ORCID,Kumar Sunny1,Ganguly Kirat K2,Ghosh Pratyay3,Tabassum Shaheda1,Basu Bhaskar1,Basu Malini4

Affiliation:

1. Cancer Biology & Inflammatory Disorder Division, Council of Scientific & Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), TRUE Campus, CN-6, Sector V, Salt Lake, Kolkata, 700091 & 4, Raja S.C. Mullick Road, Jadavpur, Kolkata, 700032, India

2. Department of Microbiology, Michael Madhusudan Memorial College, Durgapur, 713216, India

3. Department of Electronics & Instrumentation Engineering, Techno India College (Main), EM-4/1, Sector-V, Salt Lake, Kolkata, 700091, India

4. Department of Microbiology, Dhruba Chand Halder College, University of Calcutta, Kolkata, 743372, India

Abstract

The COVID-19 outbreak has created disaster globally, and mankind is yet to come in terms with combating this global menace. Amid this turmoil, immunocompromised individuals like cancer patients exhibit dismal immune responses toward such infection. In order to treat cancer patients during such adverse situations, it is necessary to understand the phenomena that interlink these two diseased states. Modulation of host epigenetic landscape is a key hallmark of both cancer and viral infections, including COVID-19. Our review aims to shed light upon the interplay between COVID-19 and cancer, primarily through the genetic and epigenetic modulations of the gene expression profile, so as to design better therapeutic strategies in the near future.

Funder

Science and Engineering Research Board

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

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