Light-triggered crosslinking of gold nanoparticles for remarkably improved radiation therapy and computed tomography imaging of tumors-Reference-Cited by-同舟云学术

Light-triggered crosslinking of gold nanoparticles for remarkably improved radiation therapy and computed tomography imaging of tumors

Published:2019-11 Issue:22 Volume:14 Page:2941-2955
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Cheng Xiaju¹²,Sun Rui¹,Xia Huawei¹,Ding Jianan¹,Yin Ling³⁴,Chai Zhifang¹,Shi Haibin¹,Gao Mingyuan¹⁵

Affiliation:

1. State Key Laboratory of Radiation Medicine & Protection, School for Radiological & Interdisciplinary Sciences (RAD-X) & Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, PR China

2. Jiangsu Key Laboratory of Infection & Immunity, Institutes of Biology & Medical Sciences, Soochow University, Suzhou 215123, PR China

3. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering & Materials Science & Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou 215123, PR China

4. Department of Chemistry & Chemical Engineering, Jining University, Qufu 273155, PR China

5. Institute of Chemistry, Chinese Academy of Sciences, School of Chemistry & Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China

Abstract

Aim: We aimed to characterize the tumor-targeting and radiosensitization properties of the photo-responsive gold nanoparticles (AuNPs) decorated photolabile diazirine group and folic acid for improved radiotherapy and computed tomography imaging of tumors. Methods: Folic acid and photolabile diazirine group were covalently conjugated on the surface of AuNPs to afford the desired photo-responsive dAuNP-FA (AuNPs capped with poly(ethylene) glycol ligands bearing photolabile diazirine group and folic acid). The probes were intravenously injected into tumor-bearing mice followed by photocrosslinking upon 405 nm laser irradiation for radiotherapy and computed tomography imaging of tumors in vivo. Results: Light-triggered crosslinking of AuNPs in vivo remarkably enhanced the accumulation and retention of AuNPs within tumors. Conclusion: We have successfully developed a novel photo-responsive Au particle-based tumor theranostic probe showing remarkably improved tumor targeting ability and radiosensitization effect.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0015

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