Development of a nanodrug-delivery system camouflaged by erythrocyte membranes for the chemo/phototherapy of cancer-Reference-Cited by-同舟云学术

Development of a nanodrug-delivery system camouflaged by erythrocyte membranes for the chemo/phototherapy of cancer

Published:2020-03 Issue:7 Volume:15 Page:691-709
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Daniyal Muhammad¹,Jian YuQing¹,Xiao Feng²,Sheng Wenbing¹,Fan Jialong²,Xiao Chang²,Wang Zhou²,Liu Bin²,Peng Caiyun¹,Yuhui Qin¹,Wang Wei¹^ORCID

Affiliation:

1. TCM & Ethnomedicine Innovative & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan ,410208, PR China

2. College of Biology, Hunan University, Changsha, 410082, PR China

Abstract

Aim: Development of a new drug-delivery system using a compound derived from Pronephrium penangianum (J5) for the treatment of cervical cancer. Materials & methods: The delivery system was developed using Prussian blue nanoparticles, camouflaged by red blood cell membrane and with folic acid surface modifications. Results: Our results showed the successful development of a nanodrug-delivery system, which increases the half-life and immune evasion ability of the drug. The mechanism of this system was through suppressing B-cell lymphoma 2 and increasing B-cell lymphoma 2-associated X protein and the cleaved caspase level. An in vivo study also confirmed good antitumor activity without any side effects to normal tissue. Conclusion: This drug-delivery system provides a good alternative for the treatment of cervical cancer using J5.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0454

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