miRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia-Reference-Cited by-同舟云学术

miRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia

Published:2020-05 Issue:11 Volume:15 Page:1113-1126
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Phạm Thuỳ Linh¹²,Yin Yuhua¹²³,Kwon Hyeok Hee¹²,Shin Nara¹²,Kim Song I¹²,Park Hyewon¹²,Shin Juhee¹²,Shin Hyo Jung¹²,Hwang Jeong-Ah¹²,Song Hee-Jung⁴,Kim Sang Ryong⁵,Lee Joo Hyoung⁶,Hwang Patrick T J⁷,Jun Ho-Wook⁷,Kim Dong Woon¹²^ORCID

Affiliation:

1. Department of Medical Science, Chungnam National University College of Medicine, Daejeon, 35015, Republic of Korea

2. Department of Anatomy and Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon, 35015, Republic of Korea

3. Department of Anesthesia, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, Guangdong Province, PR China

4. Department of Neurology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon, 35015, Republic of Korea

5. School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Institute of Life Science & Biotechnology, Brain Science & Engineering Institute, Kyungpook National University, Daegu, 41566, Republic of Korea

6. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA

7. Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA

Abstract

Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-κB and p38 MAPK pathways in spinal microglia. Materials & methods: After NP preparation, miR NPs were assessed for their physical characteristics and then injected intrathecally into the spinal cords of rat spinal nerve ligation rats to test their analgesic effects. Results: miR NPs reduced pain behaviors for 11 days by negatively regulating the inflammatory response in spinal microglia. Conclusion: The anti-inflammatory effects of miR 146a-5p along with nanoparticle-based materials make miR NPs promising tools for treating neuropathic pain.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0462

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