Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy-Reference-Cited by-同舟云学术

Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy

Published:2020-04 Issue:8 Volume:15 Page:793-808
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Berber Mohamed R¹²³,Elkhenany Hoda⁴⁵^ORCID,Hafez Inas H¹⁶,El-Badawy Ahmed⁴,Essawy Mohamed⁴,El-Badri Nagwa⁴

Affiliation:

1. Center for Nanotechnology (CNT), Zewail City of Science & Technology, 6th October City, Giza, 12578, Egypt

2. Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt

3. Department of Chemistry, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia

4. Center of Excellence for Stem Cells & Regenerative Medicine (CESC), Zewail City of Science & Technology, 6th October City, Giza, 12578, Egypt

5. Department of Surgery, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21944, Egypt

6. Department of Natural Resources & Agricultural Engineering, Faculty of Agriculture, Damanhour University, Damanhour, 22516, Egypt

Abstract

Aim: Therapeutically targeting cancer stem cells (CSCs), which play a role in tumor initiation and relapse, remains challenging. Materials & methods: Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their effect on CSCs was evaluated. Results: Pt-NPs showed homogenous distribution on the surface of MWCNT/PBI composites, with very narrow particle size. MWCNT/PBI/Pt-NPs resulted in a dramatic decrease in the proliferation rate of CSCs but not bone marrow mesenchymal stem cells (BM-MSCs). Quantitative gene expression analysis revealed that MWCNT/PBI/Pt had a significant inhibitory effect on the epithelial-mesenchymal transition and cell cycle markers of CSCs. Conclusion: MWCNT/PBI/Pt exhibited a specific cytotoxic effect on breast CSCs but not on adult stem cells.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0445

Reference64 articles.

1. Epithelial-Mesenchymal Plasticity of Breast Cancer Stem Cells: Implications for Metastasis and Therapeutic Resistance

2. Breast Cancer Stem Cells as Drivers of Tumor Chemoresistance, Dormancy and Relapse: New Challenges and Therapeutic Opportunities

3. Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers

4. High Electronic Conductivity and Air Stability of Ultrasmall Copper-Metal Nanoparticles Supported on Pyridine-Based Polybenzimidazole Carbon Nanotube Composite

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