The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma-Reference-Cited by-同舟云学术

The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma

Published:2019-08 Issue:15 Volume:14 Page:2027-2043
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Shi Lei¹^ORCID,Liu Pei¹,Wu Jing²,Ma Lun³,Zheng Han³,Antosh Michael P⁴⁵,Zhang Haiyan¹,Wang Bo¹,Chen Wei³,Wang Xiuli¹

Affiliation:

1. Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, PR China

2. Department of Computer Science & Statistics, University of Rhode Island, 9 Greenhouse Rd, Kingston, RI 02881, USA

3. Department of Physics, the University of Texas at Arlington, Arlington, TX 76019-0059, USA

4. Physics Department, University of Rhode Island, 2 Lippitt Rd, Kingston, RI 02881, USA

5. Institute for Brain & Neural Systems, Brown University, 184 Hope St, Providence, RI 02912, USA

Abstract

Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanoparticles were used as a photosensitizer of X-PDT. The dark toxicity and cytotoxicity were studied in vitro. Tumor volume, microvessel density and acute toxicity of mice were evaluated in vivo. Results: Without x-ray irradiation, copper-cysteamine nanoparticles were nontoxic for keratinocyte cells. XL50 cells (SCC) were more sensitive to X-PDT than B16F10 cells (melanoma). X-PDT successfully inhibited the growth of SCC in vivo (p < 0.05), while the B16F10 melanoma was resistant. Microvessel density in SCC tissue was remarkably reduced (p < 0.05). No obvious acute toxicity reaction was observed. Conclusion: X-PDT is a safe and effective treatment for SCC.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0094

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