Nanotechnology-based delivery systems in HIV/AIDS therapy

Abstract

The therapeutic efficacy of anti-HIV agents is often hampered by poor bioavailability and lack of drug penetration in infected target tissues and cells. Using different types of nanotechnology-based delivery systems, it is possible to engineer strategies that can improve the therapeutic efficacy in HIV/AIDS by delivering drugs to cellular and anatomical viral reservoirs. The rationale for the use of nanocarrier systems relies on the fact that different types of therapeutic payloads can be encapsulated and the systemic pharmacokinetics and distribution are dictated by the properties of the nanocarriers rather than the drugs. The versatility of nanoplatforms can be further exploited in a formulation that has enhanced oral bioavailability, protects against degradation upon oral or systemic administration and prolongs the residence time at the target site. Nanocarriers can facilitate lymphatic transport, delivery across the blood–brain barrier, and efficient internalization in cells by nonspecific or receptor-mediated endocytosis. In this review, we will address the role of nanotechnology-based delivery systems in improving the delivery efficiency of anti-HIV drugs to cellular and anatomical sites of interest. Specific published examples will be highlighted with emphasis on the role of polymeric nanoparticle micelles, liposomes and nanoemulsions in improving delivery efficiency.