Mechanisms of action of the mood stabilizer valproate: a focus on GSK-3 inhibition

Author:

Azab Abed N1,Ishak Julia F2,Kaplanski Jacob3,Delbar Vered1,Greenberg Miriam L4

Affiliation:

1. Ben-Gurion University of the Negev, School for Community Health Professions, Faculty of Health Sciences, PO Box 653, Beer-Sheva 84105, Israel.

2. Ben-Gurion University of the Negev, Medical School for International Health, Faculty of Health Sciences, PO Box 653, Beer-Sheva 84105, Israel.

3. Ben-Gurion University of the Negev, Department of Clinical Pharmacology, Faculty of Health Sciences, PO Box 653, Beer-Sheva 84105, Israel.

4. Wayne State University, Department of Biological Sciences, Detroit, MI 48202, USA.

Abstract

Valproate is the most widely prescribed antiepileptic drug worldwide, and it is also used in the treatment of bipolar affective disorder, migraine headache and cancer. However, the therapeutic mechanism of action of valproate in these illness states is not understood. This article reviews the pharmacological effects of valproate that may explain its therapeutic efficacy. It focuses on the hypothesis that inhibition of glycogen synthase kinase-3 by valproate is a crucial therapeutic mechanism of this drug in the treatment of bipolar affective disorder. Other cellular pathways and signaling molecules that are targets of valproate (such as inositol de novo biosynthesis, histone deacetylase, protein kinase C, γ-aminobutyric acid, the extracellular signal-regulated kinase pathway and others) are also discussed.

Publisher

Future Medicine Ltd

Subject

Clinical Neurology,Neurology

Reference141 articles.

1. Basic Pharmacology of Valproate

2. LoscherW: Valproic acid mechanisms of action. In:Antiepileptic Drugs.Levy RH, Mattson RH, Meldrum BS, Perucca E (Eds). Lippincott Williams & Wilkins, PA, USA767–779 (2002).

3. Pharmacological and Therapeutic Properties of Valproate

4. Bipolar Disorder

5. Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3