CAR therapy for hematological cancers: can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies?

Author:

Pegram Hollie J1,Smith Eric L1,Rafiq Sarwish1,Brentjens Renier J123

Affiliation:

1. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

2. Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA

3. Molecular Pharmacology & Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Abstract

Chimeric antigen receptor (CAR) T-cell therapy has recently come into the spotlight due to impressive results in patients with B-cell acute lymphoblastic leukemia. By targeting CD19, a marker expressed most B-cell tumors, as well as normal B cells, CAR T-cell therapy has been investigated as a treatment strategy for B-cell leukemia and lymphoma. This review will discuss the successes of this therapy for the treatment of B-cell acute lymphoblastic leukemia and the challenges to this therapeutic strategy. We will also discuss application of CAR T-cell therapy to chronic lymphocytic leukemia and other B-cell malignancies including a follicular lymphoma, diffuse large B-cell lymphoma, as well as acute and plasma cell malignancies.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

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